In stock

Thymosin Alpha-10mg

£19.95

Thymosin Alpha-1 is a synthetic immunomodulatory peptide developed for experimental investigation of T-cell signalling, immune system regulation, and peptide-mediated cellular communication pathways.

Batch tested Purity: ≥ 98.5 % (HPLC, typical)
CAS Number: 62304-98-7
Molecular Formula: C129H215N33O55
Amino Acid Sequence: Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN (28-mer, N-acetylated)

Available: In stock Category: Peptides Tag: 10 MG

Description

Thymosin Alpha-1

Synonyms / Designations: Thymosin Alpha-1, Tα1, Thymosin α1, Thymalfasin
CAS Number: 62304-98-7
Molecular Formula: C129H215N33O55
Molecular Weight: ~3108.32 g/mol
Peptide Length: 28 amino acids
Peptide Type: Synthetic immunomodulatory peptide (thymic peptide analogue)
Purity: ≥ 99 % (HPLC, typical)
Appearance: White to off-white lyophilised powder
Pack Size: 5 mg (typical)
Storage: Desiccated, protected from light, stored at –20 °C or below
Solubility: Soluble in water and buffered aqueous solutions

Description & Mechanism

Thymosin Alpha-1 is a synthetic 28-amino-acid peptide corresponding to an active fragment of the endogenous thymic hormone prothymosin-α. It is widely used in experimental research to investigate immune system regulation, peptide–receptor interactions, and intracellular signalling pathways involved in innate and adaptive immunity.

In biochemical and cellular research systems, Thymosin Alpha-1 has been shown to modulate immune-related signalling pathways, including those associated with antigen presentation, cytokine expression, and T-cell differentiation. Experimental studies commonly examine its influence on toll-like receptor signalling, NF-κB activation, and interferon-related pathways. Observed molecular responses are dependent on concentration, exposure duration, and experimental model.

Applications in Research

As a molecular probe for studying immune modulation and thymic peptide signalling.
Investigation of innate and adaptive immune pathway regulation in cellular models.
In vitro studies examining cytokine signalling, antigen presentation, and T-cell activation.
Use as a reference peptide in immunology, inflammation, and host-defence research.

Specifications Summary

Purity (HPLC): ≥ 99 %
Appearance: White to off-white lyophilised powder
Molecular Weight: ~3108.32 g/mol
Peptide Type: Synthetic thymic peptide analogue
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: 5 mg

Handling, Reconstitution & Stability

Weigh under dry conditions; peptide is hygroscopic.
Reconstitute in sterile water or appropriate buffered aqueous solution.
Avoid vigorous agitation during dissolution.
Filter sterilize if required (e.g. 0.22 µm) prior to use.
Aliquot and store reconstituted solutions at –20 °C or lower.
Avoid repeated freeze–thaw cycles.

Precautions & Notes

Experimental behaviour is influenced by immune cell type, receptor expression, concentration, and exposure duration.
Buffer composition, pH, and ionic strength may affect peptide stability.
Appropriate controls are recommended.
Intended strictly for laboratory research use.

References

Goldstein A.L. et al. Thymosin alpha 1: biological activity and clinical applications. Annals of the New York Academy of Sciences, 2007.
https://pubmed.ncbi.nlm.nih.gov/17660844/

Romani L. et al. Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance. Blood, 2004.
https://pubmed.ncbi.nlm.nih.gov/15026312/

Garaci E. et al. Thymosin alpha 1 in immune regulation. International Journal of Immunopharmacology, 1998.
https://pubmed.ncbi.nlm.nih.gov/9802921/

Keywords: Thymosin Alpha-1, Tα1, Thymalfasin, Immunomodulatory Peptide, Synthetic Thymic Peptide