In stock

KPV 10mg

£19.90

KPV (Lys–Pro–Val) is a tripeptide derived from the C-terminal fragment of α-melanocyte-stimulating hormone (α-MSH 11–13), used in experimental research to investigate melanocortin-related signalling and inflammation-associated cellular pathways.

Batch tested Purity: ≥ 99 % (HPLC, typical)
CAS Number: 67727-97-3
Peptide Type: Synthetic tripeptide (α-MSH(11–13) / ACTH(11–13) fragment)
Amino Acid Sequence: Lys-Pro-Val (KPV)

Available: In stock Category: Peptides Tag: 10 MG

Description

KPV

Synonyms / Designations: KPV, Lys–Pro–Val, α-MSH (11–13), α-Melanocyte-Stimulating Hormone fragment
CAS Number: 67727-97-3
Molecular Formula: C15H26N4O4
Molar Weight: ~342.43 g/mol
Peptide Sequence: Lys–Pro–Val
Peptide Classification: Synthetic tripeptide; α-MSH–derived fragment
Purity: ≥ 99 % (HPLC, typical)
Appearance: White to off-white lyophilised powder
Pack Size: 5 mg (typical)
Storage: Desiccated, protected from light, stored at –20 °C
Solubility: Soluble in sterile water and buffered aqueous solutions

Description & Mechanism

KPV is a synthetic tripeptide corresponding to amino acids 11–13 of α-melanocyte-stimulating hormone (α-MSH). It represents the minimal bioactive fragment commonly utilised in research settings to investigate melanocortin-associated signalling independently of the full-length peptide.

In biochemical and cellular research systems, KPV has been studied for its interactions with melanocortin-related pathways and downstream intracellular signalling mechanisms associated with immune modulation and inflammatory responses. Experimental studies typically examine receptor-independent and receptor-associated signalling effects, transcriptional responses, and peptide stability under controlled conditions. Observed molecular responses are dependent on experimental design, concentration, and model system, and are used to explore peptide-mediated signalling rather than defined biological or physiological outcomes.

Applications in Research

As a molecular probe for studying melanocortin-related signalling pathways
Investigation of peptide-mediated modulation of inflammatory and immune-associated cellular responses
In vitro studies examining short peptide signalling and stability
Use as a reference compound in melanocortin and α-MSH fragment research

Handling, Reconstitution & Stability

Weigh under dry conditions; peptide is hygroscopic
Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
Avoid vigorous agitation during dissolution
Filter sterilize if required (e.g. 0.22 µm) immediately prior to use
Aliquot and store reconstituted solutions at –20 °C (or lower)
Avoid repeated freeze–thaw cycles

Specifications Summary

Purity: ≥ 99 %
Appearance: White to off-white lyophilised powder
Peptide Type: Synthetic α-MSH–derived tripeptide
Molar Weight: ~342.43 g/mol
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: 5 mg

Precautions & Notes

Experimental behaviour of KPV is influenced by concentration, exposure duration, and experimental model
Short peptide fragments may exhibit signalling profiles distinct from parent hormones
Buffer composition, pH, and ionic strength may affect peptide stability and assay performance
Appropriate controls are recommended to distinguish specific from non-specific effects
Intended strictly for laboratory research use; not for human or veterinary application

References

Catania A. et al. The neuroimmunomodulatory role of melanocortins. Endocrine Reviews, 2004.
https://pubmed.ncbi.nlm.nih.gov/15082519/

Lipton J.M., Catania A. Anti-inflammatory actions of the neuroimmunomodulator α-MSH. Immunology Today, 1997.
https://pubmed.ncbi.nlm.nih.gov/9368769/

Brzoska T. et al. α-MSH peptides and their receptors: biological functions. Journal of Endocrinology, 2008.
https://pubmed.ncbi.nlm.nih.gov/18334621/

Schiller P.W. et al. Structure–activity relationships of melanocortin peptides and fragments. Annals of the New York Academy of Sciences.
https://pubmed.ncbi.nlm.nih.gov/9463824/

Getting S.J. et al. The melanocortin peptide KPV inhibits inflammatory signalling pathways independently of classical melanocortin receptors. Journal of Immunology.
https://pubmed.ncbi.nlm.nih.gov/12421969/

Patel H.B. et al. Anti-inflammatory effects of melanocortin peptides and minimal active fragments. British Journal of Pharmacology.
https://pubmed.ncbi.nlm.nih.gov/16783407/

PubChem. Lys–Pro–Val (KPV) peptide compound summary.
https://pubchem.ncbi.nlm.nih.gov/compound/Lys-Pro-Val

Keywords: KPV, Lys–Pro–Val, α-MSH Fragment, Melanocortin Peptide, Synthetic Tripeptide, Peptide Signalling Research